Journal
NEURON
Volume 29, Issue 1, Pages 255-266Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(01)00195-7
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Funding
- NATIONAL EYE INSTITUTE [R01EY011973] Funding Source: NIH RePORTER
- NEI NIH HHS [EY11973] Funding Source: Medline
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cGMP-gated channels are essential for phototransduction in the vertebrate retina. Here we show that the affinity of these channels for cGMP in chick cones is substantially higher during the subjective night than during the subjective day. This effect persists in constant environmental conditions after entrainment to 12:12 hr light-dark cycles in vitro or in ovo. Circadian modulation of ligand affinity is a posttranslational effect and is driven by rhythms in the activities of two protein kinases: Erk and Ca2+/calmodulin-dependent protein kinase II (CaMKII). Erk is maximally active during the subjective night, whereas CaMKII is maximally active during the subjective day. Acute inhibition of these signaling pathways causes phase-dependent changes in the affinity of the channels for cGMP.
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