Journal
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
Volume 124, Issue 1, Pages 40-45Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1067/mhn.2001.112199
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OBJECTIVE: To determine the ability of topically applied mitomycin C to create a stable tympanic membrane perforation. STUDY DESIGN AND SETTING: Twenty-four rats underwent subtotal removal of the tympanic membranes bilaterally. Forty ears received 0.2 mg/ml of mitomycin C, The remaining 8 received phosphatebuffered saline solution (control), Photographs taken every 3 to 5 days for 44 days were digitally scanned and computer analyzed to calculate the percentage of residual perforation. Application of solutions, photography, and data analysis were performed in a blinded fashion. RESULTS: The mitomycin C treated ears had delayed closure time and healing rate (from day 0 to 25) compared to the control group. All controls healed by day 14, By day 44, 92.5% of the mitomycin C treated ears healed, CONCLUSION: Mitomycin C prolongs the closure and healing rate of myringotomies in rat tympanic membranes, SIGNIFICANCE: Myringotomy with concurrent mitomycin C application may be useful for creating an animal model for chronic tympanic membrane perforation and should be tested in human beings as a method to maintain myringotomy patency for long-term ventilation.
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