Journal
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Volume 15, Issue 12, Pages 986-993Publisher
WILEY
DOI: 10.1002/rcm.329
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Monolithic columns have been successfully used with steep gradient and high flow rates for the direct analysis of a candidate pharmaceutical compound in human plasma. The monolithic columns showed excellent robustness with nearly 300 20-muL injections of plasma (diluted 1:1 with water) being made onto one column without significant deterioration in performance. The system gave excellent sensitivity with a limit of quantification of 5 ng/mL being achieved. Unlike previous methods of direct analysis the monolithic columns showed excellent resolution even after nearly 300 plasma injections. The column performance was measured before and after the analysis of the plasma samples. Copyright (C) 2001 John Wiley & Sons, Ltd.
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