Journal
JOURNAL OF NATURAL PRODUCTS
Volume 64, Issue 1, Pages 136-138Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np000426r
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Funding
- NATIONAL CANCER INSTITUTE [P01CA048112] Funding Source: NIH RePORTER
- NCI NIH HHS [P01-CA-48112] Funding Source: Medline
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Two new stilbene dimer glucosides, resveratrol (E)-dehydrodimer 11-O-beta -D-glucopyranoside (1) and resveratrol (E)-dehydrodimer 11'-O-beta -D-glucopyranoside (2), were isolated together with the known resveratrol (E)-dehydrodimer (3) and pallidol (4) from Vitis vinifera cell cultures. The structures and stereochemistry of the new compounds were determined on the basis of spectroscopic data analysis. Compounds 1 and 2 are dimers that belong to a new type of oligostilbene formed from a resveratrol unit and a resveratrol glucoside unit. Compounds 1 and 3 exhibited nonspecific inhibitory activity against cyclooxygenase-l and -2, with IC50 values in the range of 5 muM, whereas compound 4 was approximately 10-fold less active.
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