Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 112, Issue 1-2, Pages 1-14Publisher
ELSEVIER
DOI: 10.1016/S0165-5728(00)00409-4
Keywords
multiple sclerosis; experimental autoimmune encephalomyelitis; B cell; plasma cell; antibody
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There is much evidence to implicate B cells, plasma cells, and their products in the pathogenesis of MS. Despite unequivocal evidence that the animal model for MS, EAE, is initiated by myelin-specific T cells, there is accumulating evidence of a role for B cells, plasma cells, and their products in EAE pathogenesis. The role(s) played by B cells, plasma cells, and antibodies in CNS inflammatory demyelinating diseases are likely to be multifactorial and complex, involving distinct and perhaps opposing roles for B cells versus antibody. (C) 2001 Elsevier Science B.V. All rights reserved.
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