Journal
HUMAN PATHOLOGY
Volume 32, Issue 1, Pages 89-94Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/hupa.2001.21141
Keywords
breast cancer; cell cycle proteins; cyclin E
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Abnormalities of the cell cycle are present in all neoplasms. Cyclin E, which regulates the G1/S phase transition of the cell cycle, plays an important role in many different cancers. To further investigate the role of cyclin E in invasive breast ductal carcinomas in South African women, representative sections from 157 mastectomy and axillary clearance specimens were stained with the cyclin E antibody. The results were compared with known clinicopathologic prognostic factors, namely lymph node metastases, size, estrogen receptor status, and histologic grade. Positive (nuclear) cyclin E immunostaining strongly correlates with negative estrogen receptor status and high grade. These correlations may account for the observation that although cyclin E staining is associated with poor prognosis in univariate analysis, no prognostic significance remains after multivariate analysis. Copyright (C) 2001 by W.B. Saunders Company.
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