Journal
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
Volume 24, Issue 3, Pages 393-400Publisher
TAYLOR & FRANCIS INC
DOI: 10.1081/JLC-100001342
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The development and validation of an isocratic high performance liquid chromatographic procedure for the determination of trandolapril and verapamil in capsules is reported. The drugs were analysed on a LiChrosorb RP18 column with a mobile phase composed of acetonitrile -methanol-phosphate buffer pH 2.7 (40:30:20) and UV detection at 220 nm. Peak height ratios were linearly related to amounts of the drugs in the range 3-20 mug/mL. The inter-day precision (CV) obtained for the standard solutions ranged from 0.40 to 2.18% for trandolapril and from 0.35 to 2.57% for verapamil. The inter-day coefficients of variation for replicate analyses in capsules ranged from 0.5 to 2.49% for trandolapril and from 0.33 to 1.61% for verapamil. The recovery of analytes after extraction from formulations using the described method, was 99.94 +/- 1.69% and 98.13 +/- 1.20% (mean +/- SD) for trandolapril and verapamil, respectively.
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