Journal
CHANNELS
Volume 6, Issue 4, Pages 220-233Publisher
LANDES BIOSCIENCE
DOI: 10.4161/chan.21085
Keywords
phospholipid membranes; membrane tension; lipid interdigitation; MscL and MscS channels; transmembrane helices; periplasmic loop; hydrophobic mismatch; snorkeling effect; peptide tilting; pore forming peptides; peptidic pores
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Funding
- Spanish Consejo Superior de la Investigacion Cientifica (CSIC) [07_00502]
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Material properties of lipid bilayers, including thickness, intrinsic curvature and compressibility regulate the function of mechanosensitive (MS) channels. This regulation is dependent on phospholipid composition, lateral packing and organization within the membrane. Therefore, a more complete framework to understand the functioning of MS channels requires insights into bilayer structure, thermodynamics and phospholipid structure, as well as lipid-protein interactions. Phospholipids and MS channels interact with each other mainly through electrostatic forces and hydrophobic matching, which are also crucial for antimicrobial peptides. They are excellent models for studying the formation and stabilization of membrane pores. Importantly, they perform equivalent responses as MS channels: (1) tilting in response to tension and (2) dissipation of osmotic gradients. Lessons learned from pore forming peptides could enrich our knowledge of mechanisms of action and evolution of these channels. Here, the current state of the art is presented and general principles of membrane regulation of mechanosensitive function are discussed.
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