Journal
MEDICAL PHYSICS
Volume 28, Issue 1, Pages 4-10Publisher
AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS
DOI: 10.1118/1.1333409
Keywords
thermoacoustics; microwave; ultrasonics; tomography; photoacoustics
Funding
- NATIONAL CANCER INSTITUTE [R01CA071980, R29CA068562, R21CA083760] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA71980, R21 CA83760, R29 CA68562] Funding Source: Medline
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Scanning thermoacoustic tomography was explored in the microwave region of the electromagnetic spectrum. Short microwave pulses were used to induce acoustic waves by thermoelastic expansion in biological tissues. Cross sections of tissue samples were imaged by a linear scan of the samples while a focused ultrasonic transducer detected the time-resolved thermoacoustic signals. Based on the microwave-absorption properties of normal and cancerous breast tissues, the piezoelectric signals in response to the thermoacoustic contrast were investigated over a wide range of electromagnetic frequencies and depths of tumor locations. The axial resolution is related to the temporal profile of the microwave pulses and to the impulse response of the ultrasonic transducer. The lateral resolution is related to the numerical aperture of the ultrasonic transducer as well as to the frequency spectra of the piezoelectric signals in the time window corresponding to the axial resolution. Gain compensation, counteracting the microwave attenuation, was applied to enhance the image contrast. (C) 2001 American Association of Physicists in Medicine.
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