Related references
Note: Only part of the references are listed.Structural models of TREK channels and their gating mechanism
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Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors
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EMBO MOLECULAR MEDICINE (2011)
Activation of TREK Currents by the Neuroprotective Agent Riluzole in Mouse Sympathetic Neurons
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Expression of transient receptor potential channels and two-pore potassium channels in subtypes of vagal afferent neurons in rat
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Expression of Stretch-Activated Two-Pore Potassium Channels in Human Myometrium in Pregnancy and Labor
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PLOS ONE (2010)
Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design
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The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception
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EMBO JOURNAL (2009)
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EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2009)
Noradrenergic Depression of Neuronal Excitability in the Entorhinal Cortex via Activation of TREK-2K+ Channels
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics
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JOURNAL OF GENERAL PHYSIOLOGY (2009)
TWIK-1 and TREK-1 Are Potassium Channels Contributing Significantly to Astrocyte Passive Conductance in Rat Hippocampal Slices
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JOURNAL OF NEUROSCIENCE (2009)
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Inhibition of Human Two-Pore Domain K+ Channel TREK1 by Local Anesthetic Lidocaine: Negative Cooperativity and Half-of-Sites Saturation Kinetics
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GABAB Receptor Activation Inhibits Neuronal Excitability and Spatial Learning in the Entorhinal Cortex by Activating TREK-2 K+ Channels
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NEURON (2009)
Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Both TASK-3 and TREK-1 two-pore loop K channels are expressed in H295R cells and modulate their membrane potential and aldosterone secretion
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Methionine and its derivatives increase bladder excitability by inhibiting stretch-dependent K+ channels
S. A. Baker et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
TREK-1 is a novel molecular target in prostate cancer
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CANCER RESEARCH (2008)
A novel mechanism for human K2P2.1 channel Gating -: Facilitation of C-type gating by protonation of extracellular histidine residues
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Mtap2 is a constituent of the protein network that regulates twik-related K+ channel expression and trafficking
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JOURNAL OF NEUROSCIENCE (2008)
Control of the single channel conductance of K2P10.1 (TREK-2) by the amino-terminus: role of alternative translation initiation
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JOURNAL OF PHYSIOLOGY-LONDON (2008)
Temperature-sensitive TREK currents contribute to setting the resting membrane potential in embryonic atrial myocytes
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JOURNAL OF PHYSIOLOGY-LONDON (2008)
MGlu4 potentiation of K(2P)2.1 is dependant on C-terminal dephosphorylation
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MOLECULAR AND CELLULAR NEUROSCIENCE (2008)
Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium
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NEURON (2008)
Changes in expression of some two-pore domain potassium channel genes (KCNK) in selected brain regions of developing mice
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NEUROSCIENCE (2008)
Up- and down-regulation of the mechano-gated K2P channel TREK-1 by PIP2 and other membrane phospholipids
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PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel
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CIRCULATION RESEARCH (2007)
A Ba2+-resistant, acid-sensitive K+ conductance in Na+-absorbing H441 human airway epithelial cells
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AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2007)
Antipsychotics inhibit TREK but not TRAAK channels
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
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JOURNAL OF PHYSIOLOGY-LONDON (2007)
Altered acetylcholine, bradykinin and cutaneous pressure-induced vasodilation in mice lacking the TREK1 potassium channel: the endothelial link
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EMBO REPORTS (2007)
AKAP150, a switch to convert mechano-, pH- and arachidonic acid- sensitive TREK K+ channels into open leak channels
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EMBO JOURNAL (2006)
Mechanism of inhibition of TREK-2 (K2P10.1) by the Gq-coupled M3 muscarinic receptor
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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)
Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype
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NATURE NEUROSCIENCE (2006)
Gene expression of stretch-activated channels and mechanoelectric feedback in the heart
D. Kelly et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2006)
TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons
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AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)
TREK-1, a K+ channel involved in polymodal pain perception
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EMBO JOURNAL (2006)
Desensitization of mechano-gated K2P channels
E Honore et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Two-pore-domain potassium channels in smooth muscles: new components of myogenic regulation
KM Sanders et al.
JOURNAL OF PHYSIOLOGY-LONDON (2006)
The stretch-activated potassium channel TREK-1 in rat cardiac ventricular muscle
XT Li et al.
CARDIOVASCULAR RESEARCH (2006)
International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels
Y Kubo et al.
PHARMACOLOGICAL REVIEWS (2005)
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels
GA Gutman et al.
PHARMACOLOGICAL REVIEWS (2005)
International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels
SAN Goldstein et al.
PHARMACOLOGICAL REVIEWS (2005)
Angiotensin II inhibits bTREK-1 K+ channels in adrenocortical cells by separate Ca2+- and ATP hydrolysis-dependent mechanisms
JJ Enyeart et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels
J Murbartián et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton
I Lauritzen et al.
EMBO REPORTS (2005)
PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels
CMB Lopes et al.
JOURNAL OF PHYSIOLOGY-LONDON (2005)
Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK
D Kang et al.
JOURNAL OF PHYSIOLOGY-LONDON (2005)
Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine
LE Kennard et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
A phospholipid sensor controls mechanogating of the K+ channel TREK-1
J Chemin et al.
EMBO JOURNAL (2005)
Functional evidence of a role for two-pore domain potassium channels in rat mesenteric and pulmonary arteries
MJ Gardener et al.
BRITISH JOURNAL OF PHARMACOLOGY (2004)
Sortilin is essential for proNGF-induced neuronal cell death
A Nykjaer et al.
NATURE (2004)
Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane
M Gruss et al.
MOLECULAR PHARMACOLOGY (2004)
TREK-1, a K+ channel involved in neuroprotection and general anesthesia
C Heurteaux et al.
EMBO JOURNAL (2004)
TREK-1 K+ channels couple angiotensin II receptors to membrane depolarization and aldosterone secretion in bovine adrenal glomerulosa cells
JA Enyeart et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)
Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels
J Chemin et al.
EMBO JOURNAL (2003)
Inhibition of human TREK-1 channels by bupivacaine
MA Punke et al.
ANESTHESIA AND ANALGESIA (2003)
An ACTH- and ATP-regulated background K+ channel in adrenocortical cells is TREK-1
JJ Enyeart et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Forward transport: 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals
I O'Kelly et al.
CELL (2002)
Characterization of four types of background potassium channels in rat cerebellar granule neurons
J Han et al.
JOURNAL OF PHYSIOLOGY-LONDON (2002)
An intracellular proton sensor commands lipid- and mechano-gating of the K+ channel TREK-1
E Honoré et al.
EMBO JOURNAL (2002)
Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human two-pore K+ channel gene KCNK4 -: Chromosomal localization, tissue distribution and functional expression
A Ozaita et al.
MOLECULAR BRAIN RESEARCH (2002)
Functional expression of TREK-2 K+ channel in cultured rat brain astrocytes
C Gnatenco et al.
BRAIN RESEARCH (2002)
Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2
WL Gu et al.
JOURNAL OF PHYSIOLOGY-LONDON (2002)
Localization of TREK-2 K+ channel domains that regulate channel kinetics and sensitivity to pressure, fatty acids and pHi
Y Kim et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2001)
A TREK-1-like potassium channel in atrial cells inhibited by β-adrenergic stimulation and activated by volatile anesthetics
C Terrenoire et al.
CIRCULATION RESEARCH (2001)
Lipid and mechano-gated 2P domain K+ channels
AJ Patel et al.
CURRENT OPINION IN CELL BIOLOGY (2001)
Synergistic interaction and the rose of C-terminus in the activation of TRAAK K+ channels by pressure, free fatty acids and alkali
Y Kim et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2001)
Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery
AD Medhurst et al.
MOLECULAR BRAIN RESEARCH (2001)
The endocannabinoid anandamide is a direct and selective blocker of the background K+ channel TASK-1
F Maingret et al.
EMBO JOURNAL (2001)
Distribution and expression of trek-1, a two-pore-domain potassium channel, in the adult rat CNS
GJ Hervieu et al.
NEUROSCIENCE (2001)
Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors
F Lesage et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family
H Bang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
TREK-1 is a heat-activated background K+ channel
F Maingret et al.
EMBO JOURNAL (2000)
Polyunsaturated fatty acids are potent neuroprotectors
I Lauritzen et al.
EMBO JOURNAL (2000)
Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K+ channel
F Lesage et al.
FEBS LETTERS (2000)
Lysophospholipids open the two-pore domain mechano-gated K+ channels TREK-1 and TRAAK
F Maingret et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)