Journal
CHANNELS
Volume 5, Issue 5, Pages 408-421Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/chan.5.5.16470
Keywords
amino acid transporters; B(0)AT1; Tmem27; ACE2; SLC6; kidney; small intestine; renin angiotensin system; Hartnup disorder
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Funding
- Swiss National Science Foundation [31-108021/1, 31-59141.02, 31-130471/1]
- EUGINDAT
- University of Zurich
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Neutral amino acid transporters of the SLC6 family are expressed at the apical membrane of kidney and/or small intestine, where they (re-)absorb amino acids into the body. In this review we present the results concerning the dependence of their apical expression on their association to partner proteins. We will in particular focus on the situation of B(0)AT1 and B(0)AT3, which associate with members of the renin-angiotensin system (RAS), namely Tmem27 and angiotensin-converting enzyme 2 (ACE2), in a tissue specific manner. The role of this association in relation to the formation of a functional unit related to Na+ or amino acid transport will be assessed. We will conclude with some remarks concerning the relevance of this association to Hartnup disorder, where some mutations have been shown to differentially interact with the partner proteins.
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