Journal
NATURE IMMUNOLOGY
Volume 2, Issue 1, Pages 83-88Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/83210
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Funding
- NATIONAL CANCER INSTITUTE [P30CA016042] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL060658] Funding Source: NIH RePORTER
- NCI NIH HHS [CA16042] Funding Source: Medline
- NHLBI NIH HHS [HL60658] Funding Source: Medline
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According to the current model of adult hematopoiesis, differentiation of pluripotential hematopoietic stem cells into common myeloid- and lymphoid-committed progenitors establishes an early separation between the myeloid and lymphoid lineages. This report describes a rare and previously unidentified CD45R-CD19(+) B cell progenitor population in postnatal bone marrow that can also generate macrophages. In addition to the definition of this B-lineage intermediate, the data indicate that a developmental relationship between the B and macrophage lineages is retained during postnatal hematopoiesis.
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