Journal
CHANNELS
Volume 2, Issue 4, Pages 230-232Publisher
LANDES BIOSCIENCE
DOI: 10.4161/chan.2.4.6391
Keywords
LTP; cGKII; nitric oxide; AMPA receptor; synaptic plasticity
Categories
Funding
- NINDS NIH HHS [R01 NS049442-02, R01 NS049442-03, R01 NS049442-04, R01 NS049442] Funding Source: Medline
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Regulated trafficking of AMPA receptors (AMPARs) is an important mechanism that underlies the activity-dependent modification of synaptic strength. Trafficking of AMPARs is regulated by specific interactions of their subunits with other proteins. Recently, we have reported that the AMPAR subunit GluR1 binds the cGMP-dependent kinase type II (cGKII) adjacent to the kinase catalytic site, and that this interaction is increased by cGMP. In this complex, cGKII phosphorylates GluR1 at serine 845 (S845), a site known to be phosphorylated also by PKA. S845 phosphorylation leads to an increase of GluR1 on the plasma membrane. In neurons, cGMP is produced by soluble guanylate cyclase (sGC), which is activated by nitric oxide (NO). Calcium flux through the NMDA receptor (NMDAR) activates neuronal nitric oxide synthase (nNOS), which produces NO. Using a combination of biochemical and electrophysiological experiments, we have shown that trafficking of GluR1 is tinder the regulation of NO, cGMP and cGKII Moreover, Our study indicates that the interaction of cGKII with GluR1, which is under the regulation of the NMDAR and NO, plays an important role in hippocampal plasticity.
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