Journal
CHANNELS
Volume 2, Issue 5, Pages 358-362Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/chan.2.5.6901
Keywords
chloride-dependence; KAAT1; CAATCH1; amino acid transport; structure/function
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Funding
- Italian Ministry of Research and University [RBNE03B8KK-08]
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KAAT1 and CAATCH1 are amino acid transporters cloned from the intestine of the lepidoptera Manduca sexta.(1,2) They are members of the SLC6/NSS family, which groups membrane proteins that use Na+, K+ and Cl- gradients for the coupled transport of amines and amino acids. The report of the atomic-resolution x-ray crystal structure of the eubacterium Aquifex aeolicus leucine transporter (AaLeuT)(3) has contributed significantly to understanding of the structure-function relationship in NSS proteins. Transport by AaLeuT is Cl- independent, whereas many neurotransmitter: sodium symporters like serotonin transporter (SERT), GABA transporter (GAT1), dopamine transporter and norephinephrine transporter, among others, are strongly Cl- dependent.(4)
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