4.1 Article Proceedings Paper

Phosphoramidites and oligonucleotides containing 7-deazapurines and pyrimidines carrying aminopropargyl side chains

Journal

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 20, Issue 4-7, Pages 1421-1424

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1081/NCN-100002568

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The synthesis of phosphoramidites containing 7-deazaguanine, 7-deazaadenine, uracil and cytosine carrying aminopropargyl chains is described. The corresponding oligonucleotides are stabilized in duplexes thermally as well as against degradation by exonucleases.

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