Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 20, Issue 4-7, Pages 1271-1274Publisher
MARCEL DEKKER INC
DOI: 10.1081/NCN-100002534
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A new facile method for spin-labeling suitable for DNA and RNA oligonucleotides is presented. The nitroxide 3-ethenyl-2,2,5,5-tetramethyl-pyrrolin-1-yloxy was directly introduced during automated solid-phase synthesis by a Pd(0) cross coupling reaction. The main advantages of this procedure are the small amount of spin-label needed for the derivatisation of the oligonucleotide and the high coupling efficiency on the solid phase.
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