Journal
GENES & DEVELOPMENT
Volume 15, Issue 1, Pages 24-29Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.855301
Keywords
bHLH; math5; POU-domain; brn-3b; retinal development
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Funding
- NEI NIH HHS [R01EY11930, R01 EY011930] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY011930] Funding Source: NIH RePORTER
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math5 is a murine orthologue of atonal, a bHLH proneural gene essential for the formation of photoreceptors and chordotonal organs in Drosophila. The expression of math5 coincides with the onset of retinal ganglion cell (RGC) differentiation. Targeted deletion of math5 blocks the initial differentiation of 80% of RGCs and results in an increase in differentiated amacrine cells. Furthermore, the absence of math5 abolishes the retinal expression of brn-3b and the formation of virtually all brn-3b-expressing RGCs. These results imply that math5 is a proneural gene essential for RGC differentiation and that math5 acts upstream to activate brn-3b-dependent differentiation processes in RGCs.
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