Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 20, Issue 4-7, Pages 785-788Publisher
MARCEL DEKKER INC
DOI: 10.1081/NCN-100002430
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Cyclohexene nucleic acids (CeNA) were synthesized using classical phosporamidite chemistry. Incorporation of a cyclohexene nucleo-side in a DNA chain leads to an increase in stability of the DNA/RNA duplex. CeNA is stable against degradation in serum. A CeNA/RNA hybrid is able to activate E. Coli RNase H, resulting in cleavage of the RNA strand.
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