Journal
METABOLISM-CLINICAL AND EXPERIMENTAL
Volume 50, Issue 1, Pages 47-52Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/meta.2001.19422
Keywords
-
Categories
Funding
- NIDDK NIH HHS [DK-14507] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R37DK014507, R01DK014507] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Contributions of gluconeogenesis to glucose production were determined between 14 to 22 hours into a fast in type 2 diabetics (n = 9) and age-weight-matched controls (n = 7); ages, 60.4 +/- 2.3 versus 55.6 +/- 1.2 years and body mass indices (BMI) 28.6 +/- 2.3 versus 26.6 +/- 0.8 kg/m(2). Production was measured using a primed-continuous [6,6-H-2(2)] glucose infusion and gluconeogenesis from H-2 enrichment at carbons 2 and 5 of blood glucose on (H2O)-H-2 ingestion. plasma glucose concentration declined from 9.6 +/- 0.6 at 14 hours to 7.3 +/- 0.6 at 22 hours in the diabetics (P = .001) and from 5.4 +/- 0.1 to 5.0 +/- 0.1 in the controls (P < .05). Production from the 17(th) to 22(nd) hour declined 27.1% a 0.6% in the diabetics versus 18.5% +/- 0.8% in the controls (P = .001); from 10.4 +/- 0.3 to 7.6 +/- 0.2 versus 10.0 +/- 0.4 to 8.2 +/- 0.4 mol/kg/min. Percent contributions of gluconeogenesis to production measured at 1 1/2- to 2-hour intervals beginning the 15(th) hour were 6.8% +/- 1.0% more in the 2 diabetics than controls, The quantity of glucose contributed by gluconeogenesis declined 19.8% +/- 3.8% (P < .001) in the diabetics and 6.9% +/- 2.3% in the controls (P = .05); 7.21 +/- 0.32 to 5.74 +/- 0.26 versus 6.20 +/- 0.28 to 5.75 +/- 0.24 mol/kg/min. The contribution of glycogenolysis to production, estimated from the difference between production and gluconeogenesis, declined to the same extent in diabetic and control subjects, 40.7% +/- 6.6% and 37.7% +/- 4.1%; from 3.23 +/- 0.35 to 1.86 +/- 0.26 versus 3.81 +/- 0.22 to 2.42 +/- 0.28 mu mol/kg/min. Thus, gluconeogenesis contributed more to glucose production in the diabetic than control subjects. Production and the contribution of gluconeogenesis declined more in the diabetic subjects during the fast. The factors regulating these changes remain uncertain. Copyright (C) 2001 by W.B. Saunders Company.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available