Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 26, Issue 1, Pages 9-11Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(00)01690-X
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Using algorithms for protein sequence analysis we predict that some of the canonical type II and type IIS restriction enzymes have an active site with a substantially different architecture a nd fold from the typical PD-(D/E)xK superfamily, These results suggest that they are related to nucleases from the HNH and GIY-YIG superfamilies.
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