Journal
ARCHIVES OF VIROLOGY
Volume 146, Issue 9, Pages 1723-1738Publisher
SPRINGER WIEN
DOI: 10.1007/s007050170059
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Funding
- NCRR NIH HHS [R29 RR13209, R01 RR07849] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [R01RR007849] Funding Source: NIH RePORTER
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This report describes the isolation of CMV-like viruses from olive, yellow and chacma sub-species of baboons. The viruses were identified as CMVs by their characteristic growth properties in cell culture, virion morphology under the TEM, and antigenic cross-reactivity with other primate CMVs. The glycoprotein B gene homologue from an olive baboon CMV isolate (BaCMV OCOM4-37) was identified, cloned and sequenced. We present the sequence of this gene and by phylogenetic analysis demonstrate that BaCMV is in fact a cytomegalovirus, and is more closely related to rhesus CMV than to human CMV. An ELISA was developed to measure anti-BaCMV antibodies in baboon sera. Serological testing of colony-bred and wild-born baboons indicated that BaCMV is ubiquitous in all baboon populations, with > 95% of adult baboons of all sub-species being infected.
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