Journal
TRENDS IN NEUROSCIENCES
Volume 24, Issue 1, Pages 47-53Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0166-2236(00)01682-9
Keywords
-
Categories
Ask authors/readers for more resources
Various studies have shown that brain-derived neurotrophic factor (BDNF) increases neuronal excitability and is localized and upregulated in areas implicated in epileptogenesis, Seizure activity increases the expression of BDNF mRNA and protein, and recent studies have shown that interfering with BDNF signal transduction inhibits the development of the epileptic state in vivo, These results suggest that BDNF contributes to epileptogenesis. Further analysis of the cellular and molecular mechanisms by which BDNF influences excitability and connectivity in adult brain could provide novel concepts and targets for anticonvulsant or anti-epileptogenic therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available