Journal
BIOLOGICAL CHEMISTRY
Volume 382, Issue 1, Pages 23-30Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2001.004
Keywords
receptor-effector coupling; second messengers; signal transduction
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Muscarinic acetylcholine receptors in NG108-15 neuroblastoma x glioma cells, and beta -adrenergic or angiotensin II receptors in cortical astrocytes and/or ventricular myocytes, utilize the direct signaling pathway to ADP-ribosyl cyclase within cell membranes to produce cyclic ADP-ribose (cADPR) from beta -NAD(+), This signal cascade is analogous to the previously established transduction pathways from bradykinin receptors to phospholipase C beta and beta -adrenoceptors to adenylyl cyclase via G proteins, Upon receptor stimulation, the newly-formed cADPR may coordinately function to upregulate the release of Ca2+ from the type II ryanodine receptors as well as to facilitate Ca2+ influx through voltage-dependent Ca2+ channels, cADPR interacts with FK506, an immunosuppressant, at FKBP12.6, FK506-binding-protein, and calcineurin, or ryanodine receptors. cADPR also functions through activating calcineurin released from A-kinase anchoring protein (AKAP79), Thus, some G(q/11)-coupled receptors can control cADPR-dependent modulation in Ca2+ signaling.
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