Journal
NEUROPSYCHOPHARMACOLOGY
Volume 24, Issue 1, Pages 75-85Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0893-133X(00)00184-6
Keywords
serotonin; fluoxetine; 5-HTP; morphine; withdrawal; place conditioning
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Funding
- NIDA NIH HHS [DA06214] Funding Source: Medline
- NATIONAL INSTITUTE ON DRUG ABUSE [R37DA006214, R01DA006214] Funding Source: NIH RePORTER
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Recent studies have found that acute morphine administration increases serotonin (5-HT) transmission within the nucleus accumbens and other forebrain regions. In contrast, 5-HT transmission is depressed during withdrawal from chronic morphine. We show that pharmacological agents that increase brain 5-HT levels (fluoxetine or 5-hydoxytryptophan, 5-HTP) abolish the preference of chronically morphine-treated, withdrawn mts for a morphine-associated environment. Similar results were seen when fluoxetine was microinjected into the nucleus accumbens. Conversely, rats given morphine acutely showed an enhanced preference for a morphine-associated environment when pretreated with these agents. Fluoxetine also decreased the heightened anxiety found in morphine withdrawn rats. The results of our study indicate that drugs that augment 5-HT levels may reduce the desire for morphine during withdrawal. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
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