Journal
INTERNATIONAL JOURNAL OF HEMATOLOGY
Volume 73, Issue 1, Pages 115-118Publisher
SPRINGER JAPAN KK
DOI: 10.1007/BF02981912
Keywords
hepatitis B virus; acute myelogenous leukemia; fulminant hepatitis
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We report a case of a 41-year-old man with acute myelogenous leukemia who developed fulminant hepatitis from reactivation of trace hepatitis B virus (HBV) 2 months after complete remission. Although he became positive for HE surface antigen at the onset of fulminant hepatitis, he had been negative for HBV serum markers, and only HBV DNA was detected by polymerase chain reaction (PCR) amplification on admission. The original stocks of serum samples from all blood donors were tested again for HBV DNA by PCR, and all samples were negative. This case demonstrates that testing for HBV DNA by PCR is necessary before chemotherapy, because silent HBV carriers are rare and fulminant hepatitis may be induced by chemotherapy in patients with hematologic malignancies. (C) 2001 The Japanese Society of Hematology.
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