Journal
CEREBROVASCULAR DISEASES
Volume 31, Issue 2, Pages 163-169Publisher
KARGER
DOI: 10.1159/000321738
Keywords
Ischemic stroke; IGF-I; Pituitary dysfunction; NIHSS; Stroke outcome
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Funding
- Novo Nordisk Corp., Mainz, Germany
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Background: Pituitary dysfunction is a known complication of traumatic brain injury and subarachnoidal hemorrhage but there are few data about pituitary dysfunction as a complication of ischemic stroke. Methods: We prospectively studied patients 66-274 days after an ischemic stroke, evaluating the prevalence of pituitary dysfunction (by combined releasing hormone testing: GHRH, CRH), stroke severity, outcome and incidence of anxiety and depression. Results: Thirty-two patients (82%) presented with some degree of pituitary dysfunction with predominantly impaired growth hormone response (79.5%) and secondary adrenal failure (14.6%). Abnormal anxiety and/or depression was found in 28.3 and 32.7% of the patients. NIHSS (National Institute of Health Stroke Scale) varied between 1 and 15. Improvement in neurological deficit (Delta NIHSS) correlated significantly with NIHSS at baseline (p < 0.001) but not with pituitary function. Conclusions: Patients with ischemic stroke may suffer from pituitary dysfunction with predominantly impaired growth hormone response and secondary adrenal failure. We suggest that patients who suffer from stroke should undergo pituitary testing. Copyright (C) 2010 S. Karger AG, Basel
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