Journal
DERMATOLOGY
Volume 202, Issue 2, Pages 123-126Publisher
KARGER
DOI: 10.1159/000051611
Keywords
dermatomyositis; vasculitis; malignancy
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Background: Dermatomyositis (DM) is a rare connective tissue disease which has been shown to be associated with an underlying malignancy. Objective: Evaluation of the prevalence of malignancy in DM at our clinic and search for characteristics of the paraneoplastic form of disease. Methods: Retrospective review of patient files and histology reports over the period from 1991 to 1998, Results: 23 patients (14 women and 9 men)with DM could be identified in this time period with a median age at diagnosis of 48 years, Malignancies were found in 5 (22%) cases. The skin biopsies of all patients showed features of DM; in 7 cases, a leukocytoclastic vasculitis was detected. Four of the 5 cases with an associated malignancy demonstrated histologically a vasculitis in lesional skin, compared to only 3 out of 18 cases without malignancy (p < 0.05, Fisher's exact test). Conclusion: Our data suggest that vasculitis in lesional skin biopsies has a predictive value for the presence of underlying malignancy. Copyright <(c)> 2001 S. Karger AG. Basel.
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