Journal
CEREBROVASCULAR DISEASES
Volume 30, Issue 2, Pages 157-166Publisher
KARGER
DOI: 10.1159/000316059
Keywords
Mild cognitive impairment; Lacunar infarcts; Structural magnetic resonance; Neuropsychology
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Funding
- Generalitat de Catalunya [2005SGR00855]
- Fundacion Mapfre Medicina
- University of Barcelona
- Spanish Ministry of Science and Education [SAF2007-66270]
- Spanish Ministry of Science and Innovation [SAF2009-07489]
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Background and Method: We investigated the progression of cognitive and cerebral changes in 30 patients with a first-ever lacunar infarct (LI): 15 with vascular mild cognitive impairment (MCI-V) and 15 without cognitive impairment. All cases were followed up 18 +/- 6 months after the stroke and underwent neurological, neuropsychological and MRI assessments at baseline and longitudinally. Results: Differences in the changes in cognitive function over time were observed between the 2 groups, with the MCI-V patients showing slight memory improvements and frontal-lobe-related test impairments from baseline to follow-up evaluations. At baseline, the 2 groups presented similar white matter hyper-intensity (WMH) ratings and whole brain gray matter (GM) volumes, and at the follow-up evaluations, both groups had increased WMH lesions and decreased GM volumes; no statistical differences between groups were found. In contrast, a voxel-based morphometry analysis revealed that only MCI-V patients presented clear regional GM volume losses between the first and the second evaluations in cortical (frontal and temporal) and subcortical (pons, cerebellum and caudate) regions. Conclusion: Frontal lobe dysfunction and regional cortical and subcortical GM atrophy best differentiate the clinical course of LI patients with and without cognitive impairment. Copyright (C) 2010 S. Karger AG, Basel
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