Journal
CHEMICAL ENGINEERING JOURNAL
Volume 81, Issue 1-3, Pages 179-186Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/S1385-8947(00)00197-2
Keywords
ion exchange; protein adsorption; ionic strength; Langmuir isotherm; modeling
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An empirical model modified from the Langmuir isotherm model to account for the effects of ionic strength on the equilibrium characteristics of protein adsorption onto ion exchange/affinity adsorbents has been proposed and tested against experimental and literature data. The equilibrium isotherms for BSA adsorption onto a polystyrenic anion exchanger, Diaion HPA25, were established for five different NaCl concentrations at 25 degreesC, pH 7.0. The apparent Langmuir parameters in the new model (q(m)('), and K-d(')), which replace the Langmuir parameters (q(m) and K-d) in the original Langmuir model, were determined by non-linear curve fitting. The proposed model has been shown to be applicable to various protein/adsorbent systems. (C) 2001 Elsevier Science B.V. All rights reserved.
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