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Use of mass spectrometry-derived data to annotate nucleotide and protein sequence databases

Journal

TRENDS IN BIOCHEMICAL SCIENCES
Volume 26, Issue 1, Pages 54-61

Publisher

ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(00)01726-6

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Funding

  1. NATIONAL CANCER INSTITUTE [K01CA075447] Funding Source: NIH RePORTER
  2. NCI NIH HHS [KO1 CA75447] Funding Source: Medline

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Mass spectrometry-based proteomic methodologies can be used to annotate both nucleotide and protein sequence databases. Because such data have to be derived from proteins, they can be used to identify coding regions of the genome as weft as provide the complete primary sequence of proteins and their expression patterns and post-translational modifications.

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