Journal
CEREBROVASCULAR DISEASES
Volume 25, Issue 3, Pages 268-278Publisher
KARGER
DOI: 10.1159/000118039
Keywords
neuroprotection; brain ischaemia; stroke treatment
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Funding
- Medical Research Council [G19/24] Funding Source: Medline
- MRC [G19/24] Funding Source: UKRI
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Stroke poses a massive burden of disease, yet we have few effective therapies. The paucity of therapeutic options stands contrary to intensive research efforts. The failure of these past investments demands a thorough re-examination of the pathophysiology of ischaemic brain injury. Several critical areas hold the key to overcoming the translational roadblock: (1) vascular occlusion: current recanalization strategies have limited effectiveness and may have serious side effects; (2) complexity of stroke pathobiology: therapy must acknowledge the 'Janus-faced' nature of many stroke targets and must identify endogenous neuroprotective and repair mechanisms; repair; stroke outcome is modulated by the interaction of the injured brain with the immune system; (4) regeneration: the potential of the brain for reorganization, plasticity and repair after injury is much greater than previously thought; (5) confounding factors, long-term outcome and predictive modelling. These 5 areas are linked on all levels and therefore need to be tackled by an integrative approach and innovative therapeutic strategies. Copyright (c) 2008 S. Karger AG, Basel.
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