Journal
EUROPEAN JOURNAL OF EPIDEMIOLOGY
Volume 17, Issue 10, Pages 907-909Publisher
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1016228410194
Keywords
bias (epidemiology); cohort studies; epidemiologic methods; risk factors
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Funding
- Medical Research Council [MC_QA137853] Funding Source: Medline
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Random errors in the measurement of 10 commonly investigated cardiovascular risk factors (systolic and diastolic blood pressure, blood cholesterol, blood glucose, pulse rate, body mass index (BMI), cigarette consumption, passive smoking, alcohol intake and physical exercise) were assessed in a general population cohort (n = 2517) and a work-force cohort (n = 8008). Random errors were estimated from regression dilution ratios (lower ratios imply greater random error, and a ratio of one implies no random error). All of the risk factors, except for BMI (which had regression dilution ratios of 0.93 and 0.98 in the two cohorts), were measured with substantial levels of random error. Particularly low regression dilution ratios were observed for physical exercise (0.28 and 0.39) and pulse rate (0.47 and 0.56). For each of these risk factors, with the possible exception of BMI, associations with long-term average values could be importantly biased toward the null unless appropriate corrections are made.
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