Journal
CEREBRAL CORTEX
Volume 25, Issue 10, Pages 3802-3817Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhu262
Keywords
anterior fusiform; basal temporal language area; semantic memory; subdural electrodes; ventral anterior temporal lobe
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Funding
- MRC-UK program grant [MR/J004146/1]
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) [26282218, 26293209, 26560465]
- Japanese Ministry of Health, Labor and Welfare [H26-Nanjii-Ippan-051]
- RCUK block grant
- SPIRITS (Supporting Program for Interaction-based Initiative Team Studies) from Kyoto University
- MRC [MR/J004146/1] Funding Source: UKRI
- Grants-in-Aid for Scientific Research [15H05871, 26560465, 15H05874, 22220003, 26282218, 15H01664, 26293209, 25861273] Funding Source: KAKEN
- Medical Research Council [MR/J004146/1] Funding Source: researchfish
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Semantic memory is a crucial higher cortical function that codes the meaning of objects and words, and when impaired after neurological damage, patients are left with significant disability. Investigations of semantic dementia have implicated the anterior temporal lobe (ATL) region, in general, as crucial for multimodal semantic memory. The potentially crucial role of the ventral ATL subregion has been emphasized by recent functional neuroimaging studies, but the necessity of this precise area has not been selectively tested. The implantation of subdural electrode grids over this subregion, for the presurgical assessment of patients with partial epilepsy or brain tumor, offers the dual yet rare opportunities to record cortical local field potentials while participants complete semantic tasks and to stimulate the functionally identified regions in the same participants to evaluate the necessity of these areas in semantic processing. Across 6 patients, and utilizing a variety of semantic assessments, we evaluated and confirmed that the anterior fusiform/inferior temporal gyrus is crucial in multimodal, receptive, and expressive, semantic processing.
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