Journal
JOURNAL OF MOLECULAR EVOLUTION
Volume 52, Issue 1, Pages 78-84Publisher
SPRINGER
DOI: 10.1007/s002390010136
Keywords
sequence comparison; autolysin; lytic transglycosylase; lysozyme
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The lytic transglycosylases are a class of autolysins which cleave the bacterial cell wall heteropolymer peptidoglycan (murein) to facilitate its biosynthesis and turnover. A search of the National Center for Biotechnology Information (NCBI) databases using the primary sequences of the six characterized lytic transglycosylases of Escherichia coli; a membrane-bound form of the enzyme from Pseudomonas aeruginosa, and the endolysins of lambda bacteriophage permitted the identification of a total of 127 known and hypothetical enzymes from a wide variety of bacteria and bacteriophage. These amino acid sequences have been arranged into four families based on alignments, and consensus motifs have been identified. Family 1 represents a superfamily comprising 86 sequences which are subdivided into five (1A-1E) subfamilies.
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