Journal
JOURNAL OF FOOD SCIENCE
Volume 80, Issue 2, Pages C234-C240Publisher
WILEY
DOI: 10.1111/1750-3841.12743
Keywords
cellular glucose consumption; phenolics; Prunus avium
Categories
Funding
- Natl. Natural Science Foundation of China [31171668]
- Natl. Key Technology Research and Development Program of the Ministry of Science and Technology of China [2012BAD38B03]
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A variety of phenolics had been found to be functional in promoting cellular glucose consumption that is important for blood glucose regulation. Sweet cherry (Prunus avium) is rich in such kinds of phenolics, including hydrocinnamic acids, anthocyanins, flavonols, and flavan-3-ols. Furthermore, a sweet cherry phenolics-rich extract (PRE) was found to be effective in promoting HepG2 glucose consumption. Seventeen components were preliminarily identified by HPLC-ESI-MS, including 9 hydrocinnamic acids, 4 anthocyanins, 3 flavonols, and 1 flavan-3-ol. To investigate the cellular glucose consumption-promotion activity of different phneolics subclasses, the phenolics were further fractionated into an anthocyanin-rich fraction (ARF), hydrocinnamic acid-rich fraction (HRF), and flavonol-rich fraction (FRF) through liquid-liquid extraction and mix-mode cation-exchange solid-phase extraction. The 3 fractions promoted HepG2 glucose consumption to different levels, with the promotion effects of HRF and FRF stronger than that of the ARF. The results provide guidance on the use of sweet cherry as a functional fruit. Practical Application Provision of guidance on the application of sweet cherry as a functional fruit.
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