Journal
CEREBRAL CORTEX
Volume 25, Issue 1, Pages 221-235Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bht216
Keywords
layer 1; motor thalamic neurons; sindbis viral vector; single-neuron tracing; ventral medial thalamic nucleus
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) [23700413, 25830034, 22300113, 25250006, 24500409, 24500408, 23650175, 24890179, 23115101]
- Brain and Information Science on Material Perception [23135519]
- Neuronal Diversity and Neocortical Organization [23123510, 25123709]
- Foundation of Synapse and Neurocircuit Pathology [22110007]
- Grants-in-Aid for Scientific Research [15H01430, 14J08449] Funding Source: KAKEN
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Not only inhibitory afferent-dominant zone (IZ) of the ventral anterior-ventral lateral thalamic complex (VA-VL) but also the ventral medial nucleus (VM) is known to receive strong inputs from the basal ganglia and send axons to motor areas. We previously reported differences in axonal arborization between IZ neurons and the other VA-VL neurons in rats by single-neuron tracing with viral vectors. In the present study, the axonal arborization of single VM neurons was visualized by the same method, and compared with that of IZ neurons. VM neurons formed fewer axon collaterals in the striatum, but sent axon fibers more widely and more preferentially (79% of fibers) to layer 1 of cortical areas than IZ neurons. Furthermore, the VM seemed to contain at least 2 types of neurons; a major population of VM neurons sent axon fibers principally to motor-associated areas as VA-VL neurons did, and the other population projected mainly to orbital or cingulate areas. Although both VM and IZ neurons receive strong basal ganglia inputs, these results suggest that VM neurons, at a single neuron level, innervate the apical dendrites of cortical pyramidal neurons more intensely and more widely than IZ neurons.
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