Journal
BIOCHIMIE
Volume 83, Issue 1, Pages 25-32Publisher
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0300-9084(00)01230-X
Keywords
DnaA; DNA; replication; initiation; suppression
Categories
Ask authors/readers for more resources
Mutations in the Escherichia coli gene for initiation of DNA replication, dnaA, which suppress the polymerization defect and growth inhibition caused by temperature-sensitive (Ts) mutations in the polymerization gene, dnaX, are called Cs,Sx. We show here that these mutations, on their own, also cause defects in initiation, including inhibition of initiation at both low (20 degreesC) and high (44 degreesC) temperatures and asynchronous initiation at both the permissive (34 degreesC) and suppression (39 degreesC) temperatures. These findings suggests a relationship between partially defective initiation and suppression of the polymerization defect. both of which occur at 39 degreesC. (C) 2001 Societe francaise de biochimie et biologie moleculaire / Editions scientifiques et medicales Elsevier SAS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available