Journal
CEREBRAL CORTEX
Volume 25, Issue 4, Pages 869-883Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bht276
Keywords
age effects; diffusion tensor imaging; global tracking; mid-dorsolateral prefrontal cortex; planning ability
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Funding
- German Federal Ministry of Education and Research (BMBF) [01GW0710]
- European Union [223524]
- Brain-Links Brain-Tools Cluster of Excellence - German Research Foundation (DFG) [EXC 1086]
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Complex cognitive abilities such as planning are known to critically rely on activity of bilateral mid-dorsolateral prefrontal cortex (middlPFC). However, the functional relevance of the structural connectivity between left and right mid-dlPFC is yet unknown. Here, we applied global tractography to derive streamline counts as estimates of the structural connectivity between mid-dlPFC homologs and related it to planning performance in the Tower of London task across early to midadulthood, assuming a moderating effect of age. Multiple regression analyses with interaction effects revealed that streamline counts between left and right mid-dlPFC were negatively associated with planning performance specifically in early postadolescence. From the fourth life decade on, there was a trend for a reversed, positive association. These differential findings were corroborated by converging results from fractional anisotropy and white-matter density estimates in the genu of the corpus callosum where fibers connecting mid-dlPFC homologs traversed. Moreover, the results for streamline counts were regionally specific, marking the strength of mid-dlPFC connectivity as critical in predicting interindividual differences in planning performance across different stages of adulthood. Taken together, present findings provide first evidence for nonadditive effects of age on the relation between complex cognitive abilities and the structural connectivity of mid-dlPFC homologs.
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