Journal
CEREBRAL CORTEX
Volume 23, Issue 12, Pages 2956-2964Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhs285
Keywords
cerebrospinal fluid; GABA; glutamate; mood disorder; neuronal nitric oxide synthase; prefrontal cortex
Categories
Funding
- Nature Science Foundation of China [31271130, 30970928]
- Nature Science Foundation of Zhejiang Province [Y12H090054]
- Science and Technology Program of Zhejiang Province [2009C34020]
- China Scholarship Council for State Scholarship Fund [2010632112]
- China Exchange Program of the Royal Netherlands Academy of Arts and Sciences [08CDP012]
Ask authors/readers for more resources
Decreased function of the anterior cingulate cortex (ACC) is crucially involved in the pathogenesis of depression. A key role of nitric oxide (NO) has also been proposed. We aimed to determine the NO content in the cerebrospinal fluid (CSF) and the expression of NO synthase (NOS) isoforms, that is, NOS1, NOS2, and NOS3 in the ACC in depression. In depressive patients, CSF-NOx levels (the levels of the NO metabolites nitrite and nitrate) were significantly decreased (P 0.007), indicating a more general decrease of NO production in this disorder. This agreed with a trend toward lower NOS1-mRNA levels (P 0.083) and a significant decrease of NOS1-immunoreactivity (ir) (P 0.043) in ACC. In controls, there was a significant positive correlation between ACC-NOS1-ir cell densities and their CSF-NOx levels. Furthermore, both localization of NOS1 in pyramidal neurons that are known to be glutamatergic and co-localization between NOS1 and GABAergic neurons were observed in human ACC. The diminished ACC-NOS1 expression and decreased CSF-NOx levels may be involved in the alterations of ACC activity in depression, possibly by affecting glutamatergic and GABAergic neurotransmission.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available