Journal
CEREBRAL CORTEX
Volume 23, Issue 8, Pages 1849-1858Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhs169
Keywords
cortical circuitry; magnocellular; object recognition; schizophrenia; visual
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Funding
- National Institutes of Health [RO1 MH084848, R21 MH084031, R37 MH049334, P50 MH086385]
- NCRR High End Instrumentation grant [S10 RR022972]
- Graduate Center of the City University of New York
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Patients with schizophrenia exhibit cognitive and sensory impairment, and object recognition deficits have been linked to sensory deficits. The frame and fill model of object recognition posits that low spatial frequency (LSF) information rapidly reaches the prefrontal cortex (PFC) and creates a general shape of an object that feeds back to the ventral temporal cortex to assist object recognition. Visual dysfunction findings in schizophrenia suggest a preferential loss of LSF information. This study used functional magnetic resonance imaging (fMRI) and resting state functional connectivity (RSFC) to investigate the contribution of visual deficits to impaired object framing circuitry in schizophrenia. Participants were shown object stimuli that were intact or contained only LSF or high spatial frequency (HSF) information. For controls, fMRI revealed preferential activation to LSF information in precuneus, superior temporal, and medial and dorsolateral PFC areas, whereas patients showed a preference for HSF information or no preference. RSFC revealed a lack of connectivity between early visual areas and PFC for patients. These results demonstrate impaired processing of LSF information during object recognition in schizophrenia, with patients instead displaying increased processing of HSF information. This is consistent with findings of a preference for local over global visual information in schizophrenia.
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