Journal
CEREBRAL CORTEX
Volume 24, Issue 2, Pages 293-303Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhs342
Keywords
callosal projection neurons; corticofugal projection neurons; corticostriatal projection neurons; neocortex; striatum
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Funding
- CHDI
- National Institutes of Health [NS49553, NS45523, NS41590]
- Harvard Stem Cell Institute
- Jane and Lee Seidman Fund for CNS Research
- Emily and Robert Pearlstein Fund for Nervous System Repair
- International Brain Research Organization Fellowship
- McKnight Brain Research Institute/Regeneration Project Fellowship
- CNPq-Brazil fellowship
- NIH-NINDS Fogarty International Fellowship
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Corticostriatal projection neurons (CStrPN) project from the neocortex to ipsilateral and contralateral striata to control and coordinate motor programs and movement. They are clinically important as the predominant cortical population that degenerates in Huntingtons disease and corticobasal ganglionic degeneration, and their injury contributes to multiple forms of cerebral palsy. Together with their well-studied functions in motor control, these clinical connections make them a functionally, behaviorally, and clinically important population of neocortical neurons. Little is known about their development. Intratelencephalic CStrPN (CStrPN(i)), projecting to the contralateral striatum, with their axons fully within the telencephalon (intratelencephalic), are a major population of CStrPN. CStrPN(i) are of particular interest developmentally because they share hodological and axon guidance characteristics of both callosal projection neurons (CPN) and corticofugal projection neurons (CFuPN); CStrPN(i) send axons contralaterally before descending into the contralateral striatum. The relationship of CStrPN(i) development to that of broader CPN and CFuPN populations remains unclear; evidence suggests that CStrPN(i) might be evolutionary hybrids between CFuPN and deep layer CPNuin a sense chimeric with both callosal and corticofugal features. Here, we investigated the development of CStrPN(i) in miceutheir birth, maturation, projections, and expression of molecular developmental controls over projection neuron subtype identity.
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