Journal
ARCHIVES OF ORAL BIOLOGY
Volume 46, Issue 1, Pages 93-97Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0003-9969(00)00086-8
Keywords
nitric oxide; inducible nitric oxide synthase; immunohistochemistry; temporomandibular joint; synovial tissue; synovial lining
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The expression and distribution of inducible nitric oxide synthase (iNOS) was examined in 12 samples of human temporomandibular joint (TMJ) with internal derangement (ID) and four control specimens. In the diseased joints, strong or definite iNOS reactivity was expressed in synovial lining and endothelial cells; weaker activity was present in synovial fibroblasts. In contrast, although there was weak expression of iNOS in synovial fibroblasts and endothelial cells in the two control specimens, there was no iNOS staining in the synovial lining cell layers. This original report that iNOS is expressed in the synovial tissue of the temporomandibular joint indicates that nitric oxide is produced locally at least in the synovial lining in these joints when affected by internal derangement. (C) 2000 Elsevier Science Ltd. All rights reserved.
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