Journal
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 76, Issue 1-5, Pages 9-21Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-0760(00)00153-9
Keywords
cell nucleus; regulatory proteins; genomic DNA
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The cell nucleus is increasingly recognized as a spatially organized structure. In this review, the nature and controversies associated with nuclear compartmentalization are discussed. The relationship between nuclear structure and organization of proteins involved in the regulation of RNA polymerase II-transcribed genes is then discussed. Finally, very recent data on the mobility of these proteins within the cell nucleus is considered and their implications for regulation through compartmentalization of proteins and genomic DNA are discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.
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