Journal
CEREBRAL CORTEX
Volume 23, Issue 12, Pages 2965-2975Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhs286
Keywords
area 46; medial temporal lobe; memory; prefrontal cortex; rabies virus; retrograde transneuronal labeling
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [20019021, 17021050]
- Japan Science and Technology Agency, CREST
- Grants-in-Aid for Scientific Research [17021050, 24500379, 20019021] Funding Source: KAKEN
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The medial temporal lobe (MTL) is responsible for various mnemonic functions, such as association/conjunction memory. The lateral prefrontal cortex (LPFC) also plays crucial roles in mnemonic functions and memory-based cognitive behaviors, for example, decision-making. Therefore, it is considered that the MTL and LPFC connect with each other and cooperate for the control of cognitive behaviors. However, there exist very weak, if any, direct inputs from the MTL to the LPFC. Employing retrograde transsynaptic transport of rabies virus, we investigated the organization of disynaptic bottom-up pathways connecting the MTL and the inferotemporal cortex to the LPFC in macaques. Three days after rabies injections into dorsal area 46, a large number of labeled neurons were observed in the MTL, such as the hippocampal formation (including the entorhinal cortex), the perirhinal cortex, and the parahippocampal cortex. In contrast, a majority of the labeled neurons were located in the inferotemporal cortex following rabies injections into ventral area 46 and lateral area 12. Rabies injections into lateral area 9/area 8B labeled only a small number of neurons in the MTL and the inferotemporal cortex. The present results indicate that, among the LPFC, dorsal area 46 is the main target of disynaptic inputs from the MTL.
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