Journal
CEREBRAL CORTEX
Volume 22, Issue 10, Pages 2375-2391Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhr317
Keywords
barrel cortex; dendrite morphology; in vivo spiking; neural network; VPM innervation
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Funding
- Max Planck Society
- Center for Neurogenomics and Cognitive Research at the VU University Amsterdam
- NINDS [R01 NS069679]
- Klingenstein Fund
- Rita Allen Foundation
- NIGMS [T32 GM07367-35]
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Soma location, dendrite morphology, and synaptic innervation may represent key determinants of functional responses of individual neurons, such as sensory-evoked spiking. Here, we reconstruct the 3D circuits formed by thalamocortical afferents from the lemniscal pathway and excitatory neurons of an anatomically defined cortical column in rat vibrissal cortex. We objectively classify 9 cortical cell types and estimate the number and distribution of their somata, dendrites, and thalamocortical synapses. Somata and dendrites of most cell types intermingle, while thalamocortical connectivity depends strongly upon the cell type and the 3D soma location of the postsynaptic neuron. Correlating dendrite morphology and thalamocortical connectivity to functional responses revealed that the lemniscal afferents can account for some of the cell type- and location-specific subthreshold and spiking responses after passive whisker touch (e.g., in layer 4, but not for other cell types, e.g., in layer 5). Our data provides a quantitative 3D prediction of the cell type-specific lemniscal synaptic wiring diagram and elucidates structure-function relationships of this physiologically relevant pathway at single-cell resolution.
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