Journal
CEREBRAL CORTEX
Volume 22, Issue 8, Pages 1894-1903Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhr268
Keywords
attention; default mode; diffusion-weighted imaging; parietal; reorienting; resting state; social cognition; temporal
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Funding
- Medical Research Council UK [G0802146]
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) [453-08-002]
- MRC [G0802146, G0800578, G0700399] Funding Source: UKRI
- Medical Research Council [G0802146, 1022152, G0700399, G0800578] Funding Source: researchfish
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Controversy surrounds the role of the temporoparietal junction (TPJ) area of the human brain. Although TPJ has been implicated both in reorienting of attention and social cognition, it is still unclear whether these functions have the same neural basis. Indeed, whether TPJ is a precisely identifiable cortical region or a cluster of subregions with separate functions is still a matter of debate. Here, we examined the structural and functional connectivity of TPJ, testing whether TPJ is a unitary area with a heterogeneous functional connectivity profile or a conglomerate of regions with distinctive connectivity. Diffusion-weighted imaging tractrography-based parcellation identified 3 separate regions in TPJ. Resting-state functional connectivity was then used to establish which cortical networks each of these subregions participates in. A dorsal cluster in the middle part of the inferior parietal lobule showed resting-state functional connectivity with, among other areas, lateral anterior prefrontal cortex. Ventrally, an anterior TPJ cluster interacted with ventral prefrontal cortex and anterior insula, while a posterior TPJ cluster interacted with posterior cingulate, temporal pole, and anterior medial prefrontal cortex. These results indicate that TPJ can be subdivided into subregions on the basis of its structural and functional connectivity.
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