Journal
CEREBRAL CORTEX
Volume 22, Issue 12, Pages 2831-2839Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhr361
Keywords
cortical folding; diffusion tensor imaging; shape analysis
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Funding
- Northwestern Polytechnic University Foundation for Fundamental Research
- National Institutes of Health [K01 EB 006878, R01 HL087923-03S2, PO1 AG026423]
- University of Georgia
- China Government Scholarship
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Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.
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