Journal
MAMMALIAN GENOME
Volume 12, Issue 1, Pages 13-16Publisher
SPRINGER-VERLAG
DOI: 10.1007/s003350010236
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Funding
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK044073] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA011028] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC000882] Funding Source: NIH RePORTER
- NIAAA NIH HHS [R01 AA011028, R01AA11028] Funding Source: Medline
- NIDCD NIH HHS [R01 DC000882, R01DC00882] Funding Source: Medline
- NIDDK NIH HHS [R01DK44073, R01 DK044073] Funding Source: Medline
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The Sac (saccharin preference) locus affecting mouse behavioral and neural responsiveness to sweeteners has been mapped to distal Chr 4. A putative sweet taste receptor, T1R1, has been recently cloned, and the gene encoding it, Gpr70, has also been mapped to mouse distal Chr 4. To assess Gpr70 as a candidate gene for Snc, we compared the Gpr70 sequences of C57BL/6ByJ and 129P3/J mouse strains with different alleles of Snc. Using Gpr70 sequence variation between the C57BL/6ByJ and 129P3/J strains, we conducted a high-resolution analysis of the chromosomal localization of the Gpr70 and Sac loci in the F-2 hybrids and 129.B6-Sac partially congenic mice originating from these two strains, The Gpr70 gene maps proximal to Sac, which demonstrates that they are different loci.
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