Journal
TRENDS IN GENETICS
Volume 17, Issue 1, Pages 23-28Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0168-9525(00)02157-0
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Eukaryotic genomes come in a wide variety of sizes. Haploid DNA contents (C values) range >80 000-fold without an apparent correlation with either the complexity of the organism or the number of genes. This puzzling observation. the C-value paradox, has remained a mystery for almost half a century, despite much progress in the elucidation of the structure and function of genomes. Here I argue that new approaches focussing on the genetic mechanisms that generate genome-size differences could shed much light on the evolution of genome size.
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