Journal
CEREBRAL CORTEX
Volume 21, Issue 5, Pages 1155-1165Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhq187
Keywords
attention; executive function; fMRI; inferior frontal cortex; response inhibition
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Funding
- Wellcome Trust [089589/Z/09/Z]
- Medical Research Council
- Medical Research Council [G0001354, G0001354B, G1000183B] Funding Source: researchfish
- Wellcome Trust [089589/Z/09/Z] Funding Source: Wellcome Trust
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Evidence suggests that the right inferior frontal cortex (IFC) plays a specialized role in response inhibition. However, more recent findings indicate a broader role for this region in attentional control. Here, we used functional magnetic resonance imaging to examine the functional role of the right IFC in attention, inhibition, and response control in 2 experiments that employed novel variations of the go/no-go task. Across the 2 experiments, we observed a graded response in the right insula/IFC, whereby increasing response control demands led to an increase in activation. The results are consistent with the hypothesis that this region plays a key role in the integration of bottom-up, sensory information with top-down, response-related information to facilitate flexible, goal-directed behavior.
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